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Nitrosylating agents derived from nitric oxide can transiently form S-nitrosothiols (R-SNO), which act as activated intermediates that readily undergo further redox reactions, including disulfide bond formation

Some cycle the peptide with periodic breaks

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The antinociceptive effect of nicorandil in neuropathic and nociceptive pain is partially mediated via TRPV1/opioidergic signaling

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